EUROPEAN FEDERATION OF BIOTECHNOLOGY: EXBO Members

Professor Brian F.C. Clark

Institute of Molecular Biology, University of Aarhus
Gustav Wieds Vej 10
DK-8000 Aarhus C
Denmark
Phone +45 8942 5055; Fax + +45 8619 1959
E-mail clark@biobase.dk

Education

1961	PhD (Chemistry), Cambridge University
1975	ScD (Molecular Biology), Cambridge University

Career

1961-62	Research Associate, Division of Biochemistry, M.I.T.
1962-64	Visiting Fellow, Section of Biochemical Genetics, NIH, Bethesda, USA
1964-74	Member of Scientific Staff, Division of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge
1974-	Professor of Biostructural Chemistry, University of Aarhus, Denmark

Achievements

1965-66	Discovery of the Initiation Codon for protein synthesis and hence start of protein coding
1968	First crystallisation of an RNA molecule, yeast tRNAPhe
1974	Establishment of a research group for X-ray crystallographic structural determination of translation factors and complexes
1985	Determination of the first structure of a GTP-binding domain
1995	Crystal structure of the ternary complex of Phe-tRNAPhe, elongation factor Tu and GTP
1995-	Studies on the concepts of structural macromolecular mimicry

Areas of Research Interests

Macromolecular mimicry and molecular mechanism of protein synthesis
Protein engineering of factors involved in protein synthesis and explanation of function in terms of 3d structure from X-ray crystallography
Molecular and cellular mechanism of ageing
Use of phage display to identify differential cellular gene expression and to characterise mutant proteins and as a tool in functional genomics
Functional genomics and technology transfer

Outside Activities

1998-2003	Member of EMBO Council (European Molecular Biology Organization)
1998-1999	Chairman of FEBS (Federation of European Biochemical Societies)
2000-2003	President of the IUBMB (International Union of Biochemistry and Molecular Biology)
2001-	Chairman of TGIR (Task Group on International Relations) of the European Federation of Biotechnology
2001-	Member of the Board of Advisors of BankInvest
2003	Vice-Chairman of EMBO Council

Honours

1974-	Member of European Molecular Biology Organization (EMBO)
1980-	Foreign Member of the Royal Danish Academy of Sciences and Letters
1988-	Member of the Danish Academy of Natural Sciences (DNA)
1994-	Honorary Member of the Hellenic Biochemical and Biophysical Society
1997-	Honorary Doctorate from the Engelhardt Institute of Molecular Biology, Moscow
2001-	FEBS Diplôme d'Honneur

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